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KMID : 0620920180500080104
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Experimental & Molecular Medicine
2018 Volume.50 No. 8 p.104 ~ p.104
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Biological function of eosinophil extracellular traps in patients with severe eosinophilic asthma
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Choi Young-Woo
Pham Duy Le
Lee Dong-Hyun
Lee So-Hee
Kim Seung-Hyun
Park Hae-Sim
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Abstract
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Eosinophil extracellular traps (EETs), a complex of DNA fibers and cytotoxic granule proteins, are implicated in the development of asthma; however, the pathophysiological function of EETs in immune responses has not been fully determined. The present study investigated the characteristics of EETs from patients with non-severe asthma (NSA, n?=?20) and severe eosinophilic asthma (SEA, n?=?20) and evaluated EET function. The percentage of EET-forming peripheral blood eosinophils stimulated with IL-5 and LPS was significantly higher in patients with SEA than in those with NSA (P?=?0.009). This percentage negatively correlated with baseline FEV1 (r?=??0.350, P?=?0.027) and positively correlated with serum eosinophil-derived neurotoxin levels in asthmatic subjects (r?=?0.437, P?=?0.018). In addition, EET formation was markedly associated with reactive oxygen species production (r?=?0.750, P?
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KEYWORD
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Cell death and immune response, Inflammation
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